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it seems deeper than that the benefits would be less
I wouldn't say so - the deeper your rims, the more angle on the spokes, which will exaggerate the difference in angle.
Off-centre rims are basically a free lunch, giving you a significantly stronger wheel with little to no weight penalty. The only reason I could imagine not to use one is if the wheel is triplet laced and it would make the half-spoked side tighter than the double-spoked side, but I'm not sure it makes enough difference to do that.
Gonna build up some new disc road wheels soon, likely 40mm China carbon on either Hope Pro 5 or DT Swiss 180/240.
I'm debating whether to use asymmetric rims or not. I've built a 38mm deep rear one with asymmetric rim before, but it seems deeper than that the benefits would be less, as they're so stiff anyway.
Asymmetric rear, symmetric front? Asymmetric f+r?