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How knobby? It all depends on your use case.
I've used a few of the WTB options (less knobby Venture, more knobby Sendero and?), Schwalbe have the Bite and Ultrabite stuff (my partner has Ultrabite on the front), there's Cinturato M and Hutchison Toureg (I have 650B version of these on Tripster), my missus has a Teravail on the back of her Mason in 700x45 (Cannonball maybe)
Is there a go to nobbly tyre in 700x45c flavour? I've not taken the leap to tubeless yet but might like to in the future.