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Deffo not Threadripper for gaming; @CYOA just needed a metric fuckton of PCIe lanes.
If I was buying now, I'd get a Ryzen 7 7800X3D CPU, or the 12-core Ryzen 9 7900X3D for £60 more if you're gonna be doing actual work with it as well.
Motherboard depends on your peripheral demands. Expensive fast 'gaming' RAM is a waste of money. Invest in a decent cooler (I'd avoid watercooling, another waste of money unless you're overcl0xXing).
What's your budget? What will you use the system for?