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I had one of the Ultegra RX and swapped it out for a GRX 810, for the most part I think they are identical. I ran it with a 11-40T with some adjustment, and I’ve just got the GRX working 2x on a 11-42T. I’d imagine if you’re doing 1x on the Mason the Ultegra should cope fine
To answer your previous question, I’m using a CX70? (2x10 CX top pull derailleur) and it can shift into both rings on the GRX crankset fine, I guess with the Di2 you have less adjustability?
Edit: also re crank ideas, the Easton EA90 and they do a 48/30 or 46/30 gravel ring I think
GRX is considered ‘road’, and therefor won’t work with MTB.
https://bettershifting.com/di2-compatibility-mix-ultegra-dura-ace-xtr-xt-and-grx-components/