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Yeah, before I converted my partner's Sequioa to Di2, we ran a shadow cage 105 derailler on it and used a 42 cassette with something like a 32/46 double up front.
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It can, might not shift as crisp and will need the whole B screw to get there, but have done it plenty of times.
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R7000 GS may work with 11-40 and 50/34 depending on hanger
hippy
giofox
edscoble
@atz
I know that di2 ultegra can take a 40T cassette rather than just the 34T shimano say but any experience with 105 R7000 mechanical. Can that also take more or is the motor drive the key?