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I Barzo 2.35/Mezcal 2.25'ed Lesperit - reasonable success with them for the first half with 0 punctures (my event ending washouts probably more due to bad lines on ruts and poor technique on a sand corner), the lack of slick tread on the fast sections is barely gnawing when all the toughest (loose/steep/chunky) parts are really using all of the barzo's traction possible
I think I also made a conscious choice from changing from 2.4" Tan walls to the eventual grey endurance casing setup, as I'd rather some rolling and climbing inefficiency than maltimed backcountry punctures
If I was touring more champagne gravel however I might do Mezcal 2.1" front and rear so I can swap F/R as the rear wears out
Motorbikes don't have quite the same weight concerns so more material is easy to add without putting much strain on decently powered engine rather than some tired legs. Tread pattern is ment to make less difference to rolling resistance than you'd imagine, sounds and feels rough on a road though. Casing and compound is where it's at, a load of extra rubber all over might slow things down more then some extra knobs.