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thru axles are thicker / stiffer, have 'better' engagement at the dropouts so help to reduce disc brake rub, apparently safer as your wheel can't be ejected under heavy braking.
IMO 'huge improvement' is a bit of a stretch though.
i wouldn't let it sway my decision either way if i saw a particular frame that i liked.
I guess my point is that you don't have to limit your search to a frame with disc quick release spacing at the rear, which, as it was quickly replaced by thru axle spacing, limits your options considerably.