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there'd certainly be some subtlety in a completely optimised shape
There might be tiny gains at the ends which can be realised by additive manufacture which are impossible with forging plus a 5-axis closed loop CNC second operation, but as you say, even the most ardent weight weenie has other places to look before getting to $200/g savings on the stem, and sprinters looking for maximum stiffness can use 200g stems and still make the UCI minimumffor total machine weight.
Well yeah, that seems intuitively correct for sure.
But there'd certainly be some subtlety in a completely optimised shape, given you're joining two orthogonal tubes, and each end has clamps on it with chunky bits for bolts to thread into... But it probably only amounts to a handful of grams anyway.
The price of that Bastion stem! Sheesh