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I've been running 42T with 11S GRX and 11s Ultegra (no wolftooth) for ages. I'd presume the 12s stuff would allow me to do the same thing. It's not within Shimano spec but none of my bikes have been within spec for the last 10 years.
hippy-
Yeah, but one might have trouble finding a 12s 42t cassette, the usual suspects don't make them. But it does seem they do exist and more might appear later.
https://cooolstore.com/gb/cassettes/8193-kcnc-cassette-mtb-12s-9-52-sram-compatible-4710751036574.html
Samuli
My whole groupset was worn out, wouldn't have changed it just to get the new stuff. It does seem very similar to the 11s GRX, no huge improvements. The mechanical levers are similar. The tiny increase in brakepad clearance is nice, though the old ones were fine too. I think the jockey wheels are bigger, we'll see how long they last. The RD that's meant to be used with 2x is rated to be used with a 36t cassette, so that's a bit more than the stated max used to be. But there's less cassettes available with the about 40 teeth one might want for riding a loaded bike in the mountains. At least for the traditional HG freehub. I don't know if anyone has tried what the actual max might be yet. There are 45t MTB cassettes that would be interesting to try to fit, but that's for the microspline. And I think Rotor had something that could fit. The 2x stuff is made for the HG and 1x for the microspline. But I'm fine with the 36.