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Thanks @se1derful and @Velocio
Desktop:5950x / vision b550 d / vision 3090 / 64gb 3600 corsair vengeance rgb (2x32gb) / wd black sn850 4tb / noctua nh d15s / 4 x nf s12a / corsair 4000d airflow
The drive (sandisk 4tb extreme pro - not without their issues I know) is plugged in via an apple thunderbolt cable directly to the port on the motherboard. I never use it for other devices, just drives.
Thinking further on it, there is another thunderbolt port next to it that works fine...
I have a thunderbolt port that only shows attachments when I restart. So I have a drive attached to it and have to turn the computer on, then restart for it to show up. Evertim. Boi crie etc
What might the pathway for diagnosing look like - something a hammer to the bios would likely solve in one way or another?