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I think I pointed out one somewhat significant difference
It make zero difference to the person who have a preference on which side to brake on.
edscoble-
I agree with Ed.
What can be dangerous is to change from what you are used to.
Personally, I've always had my front brake on the left and rear on the right - I think this is preferable, especially for a right handed person, but any advantage of one side or the other is insignificant compared with your conditioned reflex.
clubman
I think I pointed out one somewhat significant difference - your front shifter and rear brake are relatively useless; if you've got one hand busy it's good if you can still use the rear shifter and front brake.
The other major difference it makes is that it can be a (potentially dangerous) pain in the arse if you roll the opposite way to everyone else in your country.