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make zero difference
I think I pointed out one somewhat significant difference - your front shifter and rear brake are relatively useless; if you've got one hand busy it's good if you can still use the rear shifter and front brake.
The other major difference it makes is that it can be a (potentially dangerous) pain in the arse if you roll the opposite way to everyone else in your country.
Usually, it’s just a personal preference in the end and make zero difference.