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Is it even a compromise? The speed-vs-comfort thing is always invoked, but is there actual data against Heine's thing? Or is it just habit and ride-what-you-have (which is fine)?
Heine's tests aren't perfect, but they seem pretty good? I only saw the figures available on the website, but two limitations come to mind: there might be a ceiling effect to their tyres, i.e., all compass tyres are just really good and it doesn't matter which you ride, whereas a gravelking would perform differently between sizes. Or, the effect size of interest was not determined; there may be a non-trivial difference between tyre sizes, but the tests aren't sensitive enough.
Dunno about anyone else, but I find 42s the best for roads around here given their state. I wouldn't want to ride anything less, and you're still in the Lord Jan Heine sweetspot of comfort and speed.