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Chicken and egg, innit. So dumb how many compromises anything under 54 has to cop for the sake of standard wheels.
There was an American builder in the 90s, Terry, who specialised in women's bikes. He kept the standard rear for the sake of normal gearing and used 650 fronts, which I reckon is a great compromise. No tyre rotation, but so what, compared to no toe overlap, uncompromised head angle, not overloading the headset on a stupidly short head tube, together with a standard drivetrain. I guess the biggest drawback is having to carry two tubes if you're not prepared to do a roadside patch job; meh
Looks pretty nice for a bike that should've been built around smaller wheels. I guess the weirdo 2.8 stays are helping, but the length of that head tube isn't.