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I don't have 50x11, I have 46x11 and I don't really want the 11T but that's where we are with cassettes for the most part (I've previously built custom cassettes that pushed the whole range away from 11T).
Yes, I can. Multi-day, loaded gravel rides: An Turas Mor, Badlands, Seven Serpents, Iberica Traversa, Spirit of Girona if you were silly enough to ride a gravel bike and any other tour where you're doing road and/or gravel mountains. Even pure road rides like ALPI4000 or Mille du Sud or Pendle 600 I've used my entire gear range and would've quite happily taken a lower gear.
hippy
Seriously tho, can you depict a ride where you'd need both a 50x11 gear ratio and a 34x46 considering a cadance range of 70-120?
GRX crankset 46/30 + 11-40 cassette would be plenty for most situations I'd imagine