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is wrist/hand pain inevitable after 200 miles or can things still be improved?
No, yes (aerobars is the obvious answer, changing hand position often the next).
how to make sure you have enough warm clothes?
Check the forecast and then take off at least another 5C if you're in the UK. Then think about what it will be like if you're damp and need to stand still fixing a flat in that temp for a while. Now you know roughly what to pack. It's always more than you think.
replace tyres before it's too late, got lucky buying a spare in Appleby.
Regularly inspect your tyres. Another thing mudguards ruin about life is making tyres harder to eyeball quickly.
Scraped round the Old 240 at the weekend, first audax for a long time and longest ride in some years. Felt good in parts but between Alston and Scotch Corner there were a lot of dark thoughts. Picked up a few things to improve in future and a few questions for people that have ridden more of the things:
And a few snaps: