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swedeee-
It's usually the other way around, when chain is on the 10t or 11t cog, the freehub has an advantage over the chain /chainset and rides on slapping the chain stay or causing chain to get thrown ofd.
Well sealed hubs (hope, i9, ck) naturally have more friction to over come. You can get proper freehub seal grease (even thinner than pawl grease), would very much use that and not a solvent like wd40 (which will work for today but make problem worse tomorrow) if your having freehub stiction issues.
BrickMan
I've run 42T cassettes for a long time on Di2 and we've both run road Di2 on gravel bikes. There can be some chainslap but you'd have to big fangin' in the smallest cog and suddenly stop pedaling. It's basically a non-issue. If it's a consistent problem it sounds more like the seal thing mentioned, or maybe something needs a clean - like you've over-greased the freehub or something and it's sticking a bit too much.