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I definitely notice a difference at 42. In addition to what @Acliff says, adjust workout plans to suit. Don't go too easy, but don't smash heavy volume 5 days a week. It's difficult to accept that you have to change your program. I really should start doing more stretching and mobility work too , as I'm starting to pick up strains and aches a little more
But there are people on the forum well into their 40s who have made great progress/ look fantastic .
That or start HRT .
Anyone ever worry about their testosterone levels. I’m hurtling towards 40 and understand levels start to drop.