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Simplon pass is shitty, lots of traffic including trucks.
You used to be able to use the old road for 2/3 of the ascent. Which was great as there was virtually zero traffic. I don't know if it's still usable though.
The descent down into Italy is outstanding, great surface and good sight lines so you can really commit to it and it's very fast.
If you choose to go through the Swiss Rhone valley and cross to Italy, I would take the Nufenen pass, the descent into Airolo is one of the best I have done ever.
Simplon pass is shitty, lots of traffic including trucks. If you decide to go Furka from the Oberwald side and descend to Realp, be aware as that is the "shitty side" :)