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I live in the tw postcodes, so I would probably alter it to avoid paddington at the worst times, as the a4 or Uxbridge Road don't massively appeal, especially if busy.
I've worked jobs with some sort of night shifts for basically my whole working life. So I'm well accustomed to a breakfast beer and I'm training my toddler in bar tending.
I suppose if I'm following the route I may catch into some of the groups and or stops depending on start times and conditions.
As I live in SE London I tweaked the start a bit to omit actually going into Paddington - I think I picked the route up in Hounslow.