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I am serious
I'm sure between users the issues you mentioned don't seem major.
Sterilisation deals with the Covid and other infections risks.
Replacement padding is already a thing as you say
The individual eye/visual setting must be adjustable as standard
I'd be up for it
Alyx is the only game on my VR radar however old.Half life 1 was a formative game for me and all its iterations
Well Rez VR may be one to experience too
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I am serious
If you are, I would be willing to lend a very VR-capable gaming laptop to the project for a while. The advantage there would be that the software set-up and hardware pairing would all be done and the current user of the set-up would only have to place the base stations and do room set-up. Also the technical problems (there always are, because the whole hardware/software setup is more complex than a normal gaming platform) would be known. I know it works well with VR because I used it for that before building a gaming PC.
So if you can recruit others and source the VR hardware, that's there. Might want to actually make use of the VR Games thread I started for not drowning this thread with discussion of a niche interest.
If at all serious... On the plus side, the game is a couple of years old and the hardware it was designed to show off isn't cutting edge any more. The various headsets that are good enough to enjoy the game in all have detachable, washable, replaceable padding and that would be a must because headsets can get sweaty. People might want to get their own inserts , because most of them come by default with cheaper foam inserts that soak up sweat and never really wash clean.
You'd also want to consider how adjustable the headset is for things like inter-pupil distance and for adjusting the distance of the lenses from the eye to cater for long-sightedness, astigmatism and glasses. The HTC kit is the best for that but also the most expensive.
Of course it's a great way to share COVID among friends.