I have had every drug on offer, sub compact with 6603 and 11 speed junior 14-25 cassette, in 2018
I reckon a junior cassette paired with TT rings would be the go. More teeth is better for efficiency and reducing the effect of the gaps growing instead instead of shrinking bug. If you can get more 2t jumps and even a 3t jump or two to cover the range of say, a 53/39:12-25, that's a couple of closer ratios in the middle of the range where the 1t jumps start.
It would be shit. Average cyclist would be better served by a sub compact, or whatever size keeps him in the middle of the cassette for most of the ride, yet having range enough to pedal up and down hills.
I reckon a junior cassette paired with TT rings would be the go. More teeth is better for efficiency and reducing the effect of the gaps growing instead instead of shrinking bug. If you can get more 2t jumps and even a 3t jump or two to cover the range of say, a 53/39:12-25, that's a couple of closer ratios in the middle of the range where the 1t jumps start.