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Aye I've been wanting to do this too. Shimano 12 speed road cassette and chain with axs mechs would be ideal but sram are cunts. The chainrings are supposed to be only compatible with flat top chains... I think I seen someone on weight weenies saying they had mixed and matched without issue but I don't really believe they would mesh without any issues.
Why not just use AXS derailleurs in Shimano drivetrain?