In occupational levels of exposure, if you are painting it on some leaves in the garden I'd be more wary of spilling it into waterways, or getting it in your eyes.
I have been much more cautious with it since all the law suits came to light. But yeah, those guys were spraying thousands of litres of it for decades.
And bear in mind that glyphosate is a carcinogen.
Edit: is probably a carcinogen.