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CYOA
This is basically what I do.
My PC weighs too much and is on fixed shelving behind the desk. My desk is a mechanical sit/stand desk. I have a single USB-C/TB cable (the expensive Apple one) coming from the PC to the desk, where it terminates in a CalDigit dock which then takes everything on the desk (monitor, mouse, keyboard, streamdeck, webcam, webcam, yubikey, audio interface) and still provides me with a TB port on my desk which I can easily get to and the memory card slot.
What I have sounds like what you're going for... but I didn't get there via the case front panel, the dock solved it. There's no slow down in the speed from doing this so long as you have a good dock (but it looks like you've been spendy in the past and wouldn't hesitate at something like the CalDigit TS4).