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Brommers
If you can get her a thunderbolt dock I would, then she only has to use a single cable to connect the laptop to the external screen / accessories.
If not use the built in USB hub in the external screen. Remember the other cable i mentioned in the thread? You need a Type A to B, you plug that into the screen (by the VGA port) and then then you can plug things into the USB ports on the screen to act as a hub.
Either way, I would plug the USB for the keyboard/mouse and webcam into the screen hub / thudnerbolt dock.
Recomendations
Webcam - if you can afford it, a Logitech C920 is excellent. If not I bought several of these for family members they're good for the price
https://www.amazon.co.uk/gp/product/B08D39BC1T/
My parents have one which they sit on the opposite side of the room from, we can see and hear them very clearly.
Mic - use the one built into the webcam
Speakers - personally I wouldn't bother with big desktop speakers if you are low on desk space, id use the built in ones to the laptop and then get her a comforable set of headphone for more intensive listening.
I think you mentioned it was a dell screen, they often were designed to work with a specifc sound bar, which attached to the bottom of the screen
Laptop riser - not only does one of these free up space on the desk, it will also raise the screen up higher to be more inline with the external screen. An added benefit is that the laptop will have better airflow for cooling.
Backlight for screen - even if its just a small desklamp poining at the wall, it will reduce the contrast between a bright screen and dark wall, reducing eye strain. I have done this for years and years on all my screens inc my TV.