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I agree Launchbury is a big miss. Collier has looked pretty good this season scrum time in the Quins games I've seen (admittedly not all of them). Arguably Cole has been the best 3 this season but it doesn't make any sense to bring him back.
It's odd though for the tight 5 to be a weakness of England, it was always their bread and butter. Proudfoot hasn't exactly enhanced his reputation since joining the coaching staff.
Interesting. Will Collier really isn't a great scrummaging tight head either. I think Sinckler is the best we have available. Agree re Marler, but I think have to assume that's covid related. Isiekwe is playing well at the moment but as the only real alternative is Ewells I can see why he gets it. Another bad time for Launchbury to be injured.
Dombrandt and Simmons both on fire, I would personally have been tempted to pick both (Simmons at 6) but Ludlam has played well for England and probably deserves this start. Hope to see Barbeary against Italy...