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Ohh yeah. I've been on 6800 and 5800 on 11-32 with hydro old 685 Ultegra levers for while with 46/36 up front.
But I am debating whether to get new 48/36 chain rings or try 1x like i have on my MTBs. But I fear I'll find 11-42 with long cage GRX sluggish.
Hulsroy-
I see. I have only been using a large 11-40 cassette on a few occasions on challenging terrain , i find the large jumps on 1x groupsets very limiting when tarmac is involved.
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You'll definitely feel the clutch, that's why I see so many people coming with bikes with it turned off.
Long cage doesn't help either.
Glws
Netakure
i have installed a RD-RX810 (the one for 2x group on my CX) with 6800 shifters and a 11-32 cassette and the shifting is great. very silent too ( the large jockey wheels seem to work wonders )