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Ability to use an appropriate OS for the different server and desktop use cases.
It sounds like you mean Windows 10, which is not designed to run headless 24/7. How will you handle updates which require user input and restarts?
I guess you can run Plex as a service though. And I may be overthinking your '24/7'... ;-)
It sounds like you should look at virtualisation. Your desktop OS does not need to dictate your NAS OS.
UnRAID is probably the easiest way to do this, a lot less hassle than Proxmox or ESXi.
Unless you want actual RAID?