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Greenbank-
Last time I was stung by a bee, it was on the neck.
An itchy red rash developed, and spread to my armpits and down to my crotch (as well as mild wheezing).
Anthistamines did nothing. Which was super fun.
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Bee stings - ASAP after it happens, make a paste out of baking soda and a little water and put that over the sting. Keep it on for at least 15 minutes then repeat as necessary. It neutralises the venom and reduces the histamine reaction and swelling. Lots of personal experience doing this. It does work well.
NotThamesWater
Aroogah
My understanding is once the swelling / itching is established, the histamine reaction is done, and antihistamines have no real effect.