I’d try and get as much out as possible close to the root and then get the weed killer as deep in as possible. Less risk to animals and more effective
If using roundup (ie glyphosate), it needs to be sprayed onto the leaves while the plant is active / growing.
If you chop the leaves off, and spray onto stem / roots, it doesn't work so well.
I don't think the overall health and environmental risks are fully established.
https://www.theguardian.com/environment/2019/mar/09/spray-pray-is-roundup-carcinogenic-monsanto-farmers-suing
@ChasnotRobert started
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I’d try and get as much out as possible close to the root and then get the weed killer as deep in as possible. Less risk to animals and more effective