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Depends on what you're riding. I do most of my touring on road, and my personal preference is for something under 40mm - above this and it feels sluggish when you're pushing it for days on end. Did my last tour on 35s, will probably do my next tour on the same.
Unless you're riding a bit of dirt, there's not much need for it.
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Yeah, I'm still a bit torn about this - current bike has 35mm hyper voyager tyres, which are great, but are on the edge clearance-wise for my current frame (esp. as they come up slightly large on my current rims). But as a big lad I wonder if slightly bigger would be even better for day rides and bridleway-bashing.
Ta all; am in the early days of speccing a custom frame - basically a light tourer with touring clearances for #plush and #supple big rubber (700C) - so am wondering how big to go. I guess I'm either looking at ~38mm tyres and 45mm guards, or ~40-44mm tyres and 52mm guards. Not sure I need to go wider than that, so it looks like going for canti bosses will give me lots of options.