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pit
You can. the cassettes exist and you just need a goat link hanger, of which there are many. Your main concern will be the massive jumps between gears.
@TotalShanner Not disparaging the existence of 12 speed. I'm all for it, but 11-46 was already there, and 50t expander cogs have been about for a while for 11 speed, hence my comment about the 10t since you want the benefit of both on an MTB.