• Another point I think is important is that generally, longer spacing between doses does lead to better overall protection in other vaccines.

    There is obvious uncertainty here, not least because the Pfizer and Moderna vaccines are different to traditional vaccines. However, the Moderna has shown evidence that longer spacing may be appropriate.

    With the AZ vaccine, which is the more traditional approach, my understanding is that longer spacing is almost always preferable.

    This also needs to be considered against the demographic of how the disease is spreading. Generally, it builds in the younger population, who are out and about more, and seeps into the older population.

    If we give all the vaccine to the most vulnerable, who are more likely to be holed up indoors, we will do nothing about bringing down the transmission rates in the portion of the population driving transmission. This is a strong argument for trying to spread the vaccine as widely as possible, while also imploring those who have been vaccinated to maintain social distancing etc.

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