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2x will result in a wheel which is slightly less stiff laterally, but which will make life easier for the hub flanges as there will be more material along the load path from the spoke hole to the edge of the hub flange. I suspect that in all likelihood the difference between 1x and 2x in that context would be far less significant than other factors, such as component choices and build quality.
Maybe so, but is it wrong to lace 2x?