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i can still run this frameset (fork) with mini-vs
Yes, it's fine. Mini-Vs are designed to accommodate axial runout in the rim (which as far as the brake is concerned is what asymmetric stud locaction is) without its feeding back into the cable. That's just one of the many advantages over cantilevers.
If it's centred between the dropouts, it might not be centred between the brake posts. The position tolerance when they were welded on probably wasn't super tight, and it doesn't take much to throw the angle off to a noticeable extent.