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hippy-
Sure there will be a component of rim/hub/wheel/tyre lateral deflection when say, you get out of the saddle on a Spanish "25% gentle hill" on a loaded bike days in into one of your escapades. Make sure to try that before you find out too late and we have to hear about it from Twitter.
EDIT: Just read your comment below
giofox
That's not even dust clearance, let alone mud clearance