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Shooting with a rangefinder wide open is always a bit of a gamble in terms of nailing focus. I'd imagine once you shoot enough you get a 'feel' for the right exposure. Also interesting to look at old contact sheets (e.g. Magnum and compare them to how the final print comes out. Often lots of manipulation, especially in low light, makes you realise that nailing the exposure is not the be all and end all of a good shot.
I've had a few meterless cameras before. Mainly MF though and didn't find it too much of an annoyance. However shooting MF was a completely different process to 35mm imo.
I'd be mainly using black and white film at least to begin with.
Interesting point - how does anyone find shooting dimly lit scenes/ wide open lenses with a manual camera? It's not something I'd really thought about, thinking f2 or below.