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In my (admittedly very limited) experience of playing around with topology optimization using a Markforged 3D printer, I've found that a sensible set of loading cases combined with not optimising too aggressively goes a long way. It's not hard to see how something like those lugs with tiny little 2-3 mm tendrils wouldn't be very impact tolerant...
Yes, me too.
As with all optimised geometry, form is driven by loading case.
With all the development of optimised carbon fibre frames presumably there's data describing flex during sprinting, deflection on crank strike or what happens when the bike falls over etc, but you could imagine scenario in which something so heavily optimised and directional in strength could fail in an unforseen loading scenario...