Drawback to Nest... it's really "boiler on" and "boiler off"... and that can be crappy if you have a large house and lots of radiators as you're always heating the whole house.
You can do zones though, we have two in our one bed flat, works well but our bedroom radiator is always off so we effectively have three zones but two Nests, if that make sense.
I'd agree Nests don't seem ideal for large houses which is a shame as I really like ours too.
Done a google - you can but only if your heating is piped to have zones. If it’s just one big ring then you can’t unless you put TRV controllers on from another brand.
You can do zones though, we have two in our one bed flat, works well but our bedroom radiator is always off so we effectively have three zones but two Nests, if that make sense.
I'd agree Nests don't seem ideal for large houses which is a shame as I really like ours too.