You can definitely go up to 46 with a Wolftooth imho, happy to lend you mine if you want to give it a go. That gear ratio would be orrible for anything but Badlands though.
Also, consider the length of the chain needed for that gear range
42T has me removing 1 link from a 118 chain so, yeah, what do MTBers use for their silly 50+ cassettes? I guess they're running smaller front rings but still are there longer chains?
You can definitely go up to 46 with a Wolftooth imho, happy to lend you mine if you want to give it a go. That gear ratio would be orrible for anything but Badlands though.
Also, consider the length of the chain needed for that gear range