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In case it helps anyone: my Specialized Sequoia came with an FSA chainset that's 48/32T and works with a standard 105 front derailleur. The cassette is an 11–36T Sunrace and also works with a 105 derailleur (GS cage but no extender as far as I am aware). So it's possible to make a non-GRX Shimano road setup work. Though I don't know if I would have necessarily gone for this exact setup had it not come with the bike.
Pictured with 1.9" 650B Gravel Kings (probably the largest tyre that the chainstays will clear).
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AntSel
sbbohr
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Yes indeed. The new GRX cranks have 110 BCD for the outer ring and 80 BCD for the inner ring.
My advice if you want ultra-low gearing on 2x is to buy a GRX crankset and a GRX front derailleur. You need to get the derailleur too because the chain-line for GRX is 2.5mm outboard.