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If you lace the dt swiss hubs to high profile rims they will be plenty strong, the only issue will be crosswind.
How much you weight is also quite important, at 160 pounds I had to true a 24h radial front wheel quite a few times, mind you, alu ~25mm profile rim with dt swiss rev spokes, not the best wheel setup. For ease of mind I would go 32h, I find my Mavic open pros laced to Phil hubs with the same dt swiss rev to be the right compromise between stiff and compliant.
Have them, they are great, but being only 20/24h is a big limitation as I see it. Much depends on the type of riding the op is going to do, for street riding/commuting I see no reason not to lace 32h wheels.