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RonnieOatmilk-
Yeah. You may still have a problem running all 4 at once as some motherboards are funny about running different pairs. But you shouldn't do any harm trying. It may beep at you and refuse to boot up with all 4 in, or reboot randomly, but you'll find out pretty soon and you can just take the 8GB out if that's the case.
Can always run a test
https://www.techpowerup.com/memtest64/
duncs
unless something's changed then it was always the case that mismatched RAM would end up all operating at the lower speed.
So you can have 16GB @ 1333MHz
or 24GB @ 1033MHz
so depends what you're being limited by atm