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It looks like you're right about the geometries, so that should be a non-issue.
I ran 45mm tyres with mudguards on my medium vagabond and had some issues with toe overlap at low speed.
Comparing a large Vagabond with a Large CDF on BikeInsights, it appears there's around 5 mm less distance between the pedal spindle and the tyre on a Vagabond.It is a good frame though! I'm looking into building mine up again.
Get a size larger than you would with drops and be vary of toe overlap due to the short cockpit.