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I did the big Henckels chef's knife pictured upthread with it - it wasn't overly difficult; I did half a side at a time so it involved re-clamping the knife 4 times in total.
The Edgepro system looks better in this regard as you don't have to clamp the knife or hold the clamp either - but it's 5x the cost:
https://uk.knivesandtools.eu/en/pt/-edge-pro-apex-3-sharpening-system.htm
How much of a pain is the Lansky to use on larger chef's knives?