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Well apparently having been exposed to some viruses like herpes can make immune response less effective for other viral infections, but increase protection against some bacterial infections including the plague.
I also read studies that showed mice infected with Lyme bacteria then go on to produce a lower immune response to influenza virus so there's a relationship between historic viral and bacterial exposure and how well your body will respond to future infections.
deleted
This is a v interesting point.
I believe if you have certain 'viruses' already in your system they may well not tolerate the new kid on the block so to speak.
#Hearsay