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Probably RF interference from the earth loop PC->USB interface->speaker amp - if you crank it it might sound a bit R2D2 and change as you do things on screen. An earth lift at some point in the chain should stop it - either a USB isolator or something inline between the interface and amp.
Edit: front usb could well be better - potentially better shielding on cabling and marginally further away from graphic card/chip.
Dramatic_Hammer
hippy
https://www.lfgss.com/comments/15158118/
I moved the little U-Control to a front USB and it seemed a little better although that could've been my imagination.
It's just this little thingie:
https://www.ebay.co.uk/itm/Behringer-UCA202-U-Control-USB-Audio-Interface/362958607230