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  • Probably RF interference from the earth loop PC->USB interface->speaker amp - if you crank it it might sound a bit R2D2 and change as you do things on screen. An earth lift at some point in the chain should stop it - either a USB isolator or something inline between the interface and amp.

    Edit: front usb could well be better - potentially better shielding on cabling and marginally further away from graphic card/chip.

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