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frankohara-
You could use Grand Perspective to work your way through your disk and see where the big files are. I find it very useful for getting an overview:
http://grandperspectiv.sourceforge.netCould take a while, but might be quicker than a format and reinstall.
mattioats
Strange. Are you running Dropbox? Mine goes nuts every now and again so gotta reset all the local & sync file settings